Objectives To investigate the burden of BaP in pregnant women and newborns and to discuss the relationship between BaP in cord serum and BPDE-DNA adducts in cord blood.
Methods The peripheral venous blood of 216 pregnant women during prenatal check were collected from a hospital in B city and their behavior and life style were investigated by questionnaire survey in July to December in 2012.The content of serum BaP was detected by high-performance liquid chromatography (HPLC) and the concentration of BPDE-DNA adducts in cord blood was determined by capillary electrophoresis-laser induced fluorescence immunoassay.The results in 185 paired maternal and cord samples were analyzed.
Results The detection rate of BaP in maternal and cord serum samples is 47.3% and 49.7% respectively. BaP in cord serumwas higher than that in paired maternal samples (P=0.002), but the concentration of PAH-DNA adducts in cord blood are not statistically associated with the content of BaP either in cord or maternal serum.
Conclusions The carcinogenic BaP can be detected in maternal and cord serum. The DNA damage in fetus through transplacental exposure to BaP is also confirmed.
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