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    Li Yonghong, Cheng Yibin, Gu Heng, Gu Wen, Jin Yinlong. Impacts of Prenatal Benzo (a) pyrene Exposure on the Expression of Cancer-related Gene of Fetus[J]. Journal of Environmental Hygiene, 2012, 2(3): 101-104, 111.
    Citation: Li Yonghong, Cheng Yibin, Gu Heng, Gu Wen, Jin Yinlong. Impacts of Prenatal Benzo (a) pyrene Exposure on the Expression of Cancer-related Gene of Fetus[J]. Journal of Environmental Hygiene, 2012, 2(3): 101-104, 111.
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    Impacts of Prenatal Benzo (a) pyrene Exposure on the Expression of Cancer-related Gene of Fetus

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      • Abstract
    • Objectives To explore the impacts of prenatal benzo(a) pyrene (BaP) exposure on the expression of cancer-related gene of fetus.
      Methods BaP in cord serum of 20 newborns was detected by using high-performance liquid chromatography (HPLC)/fluorescence, and the mRNA of RPL27A, NUDT2 and E2F1 in cord serum was tested by real-time PCR. The relationship between BaP exposure level and gene expression was analyzed.
      Results The average level of BaP in 20 cord serum samples was 0.38 ±0.31 ug/L and the samples were grouped into 5 groups according to BaP levels. With the increase of BaP exposure, the expression of RPL27A and NUDT2 genes showed an up-regulated trend, while E2F1 gene showed a down-regulated trend.
      Conclusion Prenatal BaP exposure might induce a change of the expression of cancerrelated genes.
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