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    Wang Jun, Huang Lihua, Jin Yinlong. Effect of Prenatal Benzo (a) pyrene Exposure on Global DNA Methylation of Fetus[J]. Journal of Environmental Hygiene, 2014, 4(2): 135-138, 142.
    Citation: Wang Jun, Huang Lihua, Jin Yinlong. Effect of Prenatal Benzo (a) pyrene Exposure on Global DNA Methylation of Fetus[J]. Journal of Environmental Hygiene, 2014, 4(2): 135-138, 142.
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    Effect of Prenatal Benzo (a) pyrene Exposure on Global DNA Methylation of Fetus

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      • Abstract
    • Objectives To explore the effect of prenatal benzo (a) pyrene exposure on the global DNA methylation of fetus.
      Methods The content of BaP in cord serum of 27 newborns was detected by using high--performance liquid chromatography (HPLC)/fluorescence. The global DNA methylation were quantified by liquid chromatography--tandemmass spectrometry (LC-MS/MS). The relationship between BaP exposure level and the status of global DNA methylation in cord blood were analyzed.
      Results The average exposure level of BaP in 27 cord serum samples was 0.185 ±0.1405 μg/L. The samples were categorized into 5 groups according to BaP levels. The levels of global DNA methylation showed a negative correlation with the increase of BaP exposure.
      Conclusions Prenatal BaP exposure was associated with lower global DNA methylation.
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