Laboratory Examination Results of Suspected Hand-Foot-and-Mouth Disease Cases in Zunyi City in 2011

Objectives To monitor the pathogens in 1 068 cases of suspected hand-foot-and-mouth disease (HFMD) in Zunyi City in 2011, to provide scientific basis for prevention and control of HFMD.

Methods Throat swab or rectal swab specimens from 1 068 cases of suspected HFMD were tested by real-time fluorescence detection (Realtime-PCR).

Results A total of 688 positive cases (62.25%) in 1 068 suspected HFMD cases were detected; among them, EV71 positive was detected in 319 cases (47.75%), CoxA16 positive was detected in 191 cases (28.59%), both EV71 and CoxA16 virus nucleic acid positive was detected in 47 cases (7.04%). Other intestinal virus-positive was detected in 111 cases (16.62%). The prevalent season was in April-December with two peaks (May-September and November-December). For positive samples, the ratio of male to female was 1.75: 1, the age of onset was mainly concentrated in 1~5 year-old children (97.09%).

Conclusion The occurrence of HFMD in 2011 was mainly in April-December in children aged 1~5 years, the main pathogens were EV71 and CoxA16, the prognosis of cases with EV71-based was more severe.