Determination of 18 Phthalates in Nail Polish by GC-MS

Objectives To establish a GC-MS method for simultaneous determinations of 18 kinds of phthalates in nail polish.

Methods Phthalates were extracted with methanol, the analysis was performed by GC-MS SCAN and SIM using DB-5MS column(30 m×0.25 mm×0.25 μm).

Results 18 phthalates could be completely separated under the condition of GC-MS. Each component can be detected greater than 0.2 μg/g. The linear range was 0.2~4 μg, relative coefficient was more than 0.998, RSD was less than 10%, and average recovery was 85%~101%.

Conclusions This detection method is simple, accurate, reproducible, and well separated. The column and instrument are less polluted. The feeder has few residues. 18 phthalates esters could be simultaneously determined in nail polish.