Objective To investigate the relationship between phthalate esters (PAEs) and thyroid cancer by comparing the levels of PAEs in the blood of thyroid cancer patients and normal population.
Methods Thirty patients with thyroid cancer and 30 healthy individuals were selected to collect their general information and serum samples. The levels of 15 PAEs contents in serum were measured by GC-MS, and the differences of PAEs contents between the two groups were compared and the relationship between PAEs exposure and thyroid cancer was explored by logistic regression analysis.
Results The monitoring results of the 15 PAEs showed that the detection rates of DEP, DIBP, DBP, DMEP, BMPP, DEEP, DPP, DCHP, and DEHP were all higher than 70%, and there were significant differences in DEP, DMEP, DBP, and DEHP contents between the two groups (P < 0.05). The median of DEHP in the case group was 204.049 μg/L (203.177 μg/L-204.563 μg/L). Multivariate logistic regression analysis revealed that DEHP expoure was a risk factor for incidence of thyroid cancer (OR=2.035, 95%CI: 1.154-3.579, P < 0.05).
Conclusion DEHP exposure may increase the risk of thyroid cancer prevalence.
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