Objective To establish an ultra-performance liquid chromatography-mass spectrometry method for direct determination of bisphenol S (BPS), bisphenol F (BPF), and bisphenol A (BPA) in drinking water.
Methods With a mobile phase of methanol-water for gradient elution, the water samples were separated on a Waters Acquity UPLC-HSS T3 column (2.1 mm×100 nm, 1.8 μm) and were then detected by electrospray ionization mass spectrometry in multi-reaction monitoring mode, and the external standard method was used for quantification.
Results This method had good chromatographic separation, and BPS, BPF, and BPA had a linear correlation coefficient of >0.997 within the range of(0.05~50.0) μg/L. The method detection limits of BPS, BPF, and BPA were 0.002, 0.05, and 0.15 μg/L, respectively, and the recovery of standard addition ranged from 90.1% to 108%, with relative standard deviations of 0.57%~5.90%.
Conclusion The method is simple, rapid, and sensitive and can be used for determining bisphenol compounds in drinking water.
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