Study on the Teratogenicity of Hexa-benzyl-hexa-aza-iso-wurtzitane in Rats

Objective  To investigate the potential impact of occupational exposure to Hexa-benzyl-hexa-aza-iso-wurtzitane (HBIW) on women of childbearing age.

Methods  Eighty eight pregnant SD rats were divided into four groups, one negative control group and three exposure groups. HBIW was administered by gavage to 3 exposure groups from the day 5 to day 19 during pregnancy at the dosage of 111mg/kg·bw, 333 mg/kg·bw and 1 000 mg/kg·bw. Body weight gain of pregnant rats, body weight, body length and tail length of live fetus and some other parameters affecting embryonic development were measured.

Results  Corpus luteum counts, nidation counts, vivifetus counts, the number of dead and reabsorbed fetus in 3 exposure groups were not significantly different from those in the negative control group (P>0.05). No deformity was observed in the fetus of all groups, the constituent ratio of all groups were not significantly different(P>0.05). The teratogenic index of HBIW was approximately equal to 5.

Conclusion  Teratogenic toxicity and maternal toxicity were not observed in rats exposed to HBIW.