Factors Affecting BHC and DDT Determination in Standard Samples by GC/MS

Objective  To improve the accuracy for determination of BHC and DDT in standard samples by gas chromatography-mass spectrometry (GC/MS).

Methods  Four affecting factors, including solvent effect, the comparison of internal and external standards, the fluctuation of instrument parameters and the selection of different fitting curves were analyzed.

Results  Solvent effect and the fluctuation of instrument parameters were the major affecting factors.

Conclusions  In order to improve the precision and accuracy for determination of BHC and DDT in samples, selecting smaller polar solvents, such as hexane and dichloromethane for dilution solvent, as well as using internal standard for quantification were recommended.