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    ZHANG Jinlei, LU Xiujuan, RUAN Wenli, WU Hongling, ZHOU Huafang. Sub-chronic Arsenic Exposure on BDNF Expression in Rats Hippocampus[J]. Journal of Environmental Hygiene, 2015, 5(2): 85-88. DOI: 10.13421/j.cnki.hjwsxzz.2015.02.001
    Citation: ZHANG Jinlei, LU Xiujuan, RUAN Wenli, WU Hongling, ZHOU Huafang. Sub-chronic Arsenic Exposure on BDNF Expression in Rats Hippocampus[J]. Journal of Environmental Hygiene, 2015, 5(2): 85-88. DOI: 10.13421/j.cnki.hjwsxzz.2015.02.001
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    Sub-chronic Arsenic Exposure on BDNF Expression in Rats Hippocampus

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      • Abstract
    • Objective To explore the expressions of BDNF in the hippocampus of rats caused by sub-chronic arsenism.
      Methods Forty SD rats were randomly divided according to body weight into 4 groups:a control group(treated with distilled water) and three arsenic exposure groups(exposure to NaAsO2 in distilled drinking water at 2.4, 12 and 60 mg/L for 100 days) with 5 female and 5 male rats in each group. The levels of brain arsenic, BDNF mRNA and the expression of BDNF protein in hippocampus were detected.
      Results Compared with the control group, the level of brain arsenic in all arsenic exposure groups was higher significantly(P < 0.05). BDNF mRNA and the expression of BDNF protein in hippocampus of all arsenic exposure groups was lower than the control group(P < 0.05).
      Conclusion BDNF mRNA and the expression of BDNF protein in rat hippocampus could be depressed by sub-chronic arsenism.
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