钼对小白鼠免疫功能的影响研究

刘佳; 胡琪; 王强; 欧阳雪; 郝丛强; 袁旺; 万京华

钼对小白鼠免疫功能的影响研究

Effects of Molybdenum on Immune Function of Mice

摘要

摘要:
目的研究钼对小白鼠免疫功能的影响。
方法通过在小白鼠日常饮水中加入不同剂量的钼(钼含量:20~500 mg/L), 采用脾脏重量和生长指数测定、腹腔巨噬细胞吞噬功能检测和体外抗体形成细胞检查法, 检测钼对小白鼠外周免疫器官脾脏、抗体生成及吞噬细胞功能的影响。
结果低剂量钼(20 mg/L)组小白鼠脾脏的重量、生长指数、抗体生成及吞噬细胞功能均高于对照组(P < 0.05);高剂量钼(500 mg/L)组小白鼠脾脏重量及生长指数、抗体生成及吞噬细胞功能低于对照组(P < 0.05)。
结论低剂量钼(20 mg/L)可使小白鼠免疫功能增强, 而高剂量钼(500 mg/L)致小白鼠免疫功能下降。

Abstract:
Objectives Study the effects of molybdenum on immune function of mice.
Methods In the mice study, adding different doses of molybdenum (20~500 mg/L) in drinking water. Detect the influence of molybdenum on mice's peropheral immune organ such as spleen, antibody forming and phagocytic function through spleen weight, growth index and phagocytosis of abdomen macrophages detection and in vitro antibody forming cell test.
Results In the group of low doses of molybdenum (20 mg/L) spleen weight, growth index, antibody generation and the function of macrophages were higher than the control group(P < 0.05); in the group of high dose of molybdenum (500 mg/L) spleen weight and growth index, antibody generation and function of macrophages were lower than the control group (P < 0.05).
Conclusions Low doses of molybdenum (20 mg/L) can make the mice's immune function enhanced. High dose of molybdenum (500 mg/L) lead to decreased immune function of mice.

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