Abstract: Disinfection by-products (DBPs) are a kind of harmful substances produced in the process of drinking water disinfection, and have become a research hotspot due to their toxicity and health risks. This paper systematically collected relevant literature, introduced the selection of internal exposure markers related to human internal exposure assessment of DBPs, and summarized the epidemiological research results of internal exposure levels of DBPs in urine, whole blood and exhaled breath and their relationship with human health obtained based on human biological monitoring technology in recent years, in order to provide scientific basis for population health risk assessment and risk control of DBPs.