Objective To investigate the influence of the duration of residence on inflammation and oxidation level in the migrant population with hypertension in Chengmai Mangrove Bay Community, Hainan Province, China.

Methods A total of 147 migrant individuals with hypertension were recruited from Chengmai Mangrove Bay Community as subjects, and according to the duration of residence, they were divided into ≤6 months group (≤6M group) and>6 months group (>6M group). The subjects were investigated in terms of general demographic features, individual lifestyle and behaviors, and family medical history, and blood samples were collected to measure the levels of four blood lipid parameters (total cholesterol TC, triglyceride TG, high-density lipoprotein cholesterol HDL-C, and low-density lipoprotein cholesterol LDL-C), plasma inflammatory factors (interleukin-6 IL-6, interleukin-8 IL-8, and tumor necrosis factor-α TNF-α), and oxidative indicators (superoxide dismutase SOD and malondialdehyde MDA). The stratified analysis was used to control the confounding factors such as age, sex, and blood pressure classification; the partial correlations analysis was used to analyze the correlation of duration of residence with blood lipids, inflammatory factors, and oxidation levels; the multivariate logistic regression analysis was used to investigate the risk factors for changes in blood lipids, inflammatory factors, and oxidation levels.

Results A total of 47 subjects were included, with 78 subjects in the ≤6M group and 69 subjects in the>6M group, and there were no significant differences between the two groups in sex, body mass index (BMI), heart rate, drinking alcohol, regular medication, education level and blood pressure classification (P>0.05). Compared with the ≤6M group, the>6M group had significant reductions in the levels of TG, TNF-α, and MDA (P>0.05). The partial correlations analysis showed that duration of residence was negatively correlated with TNF-α (r=-0.280), and MDA (r=-0.227). The multivariate logistic regression analysis showed that in the>6M group, blood pressure classification was a risk factor for TG. BMI was a risk factor for TNF-α, and thoes had the higher the BMI had the higher the serum TNF-α level. Smoking and grade hypertension were the risk factor for MDA; and those smoked or had the higher blood pressure classification had the higher the serum MDA level.

Conclusion Migrant population with hypertension living longer in Chengmai, Hainan, tends to experience a certain degree of reducing of TNF-α and MDA level.