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    高四红, 邹钦培, 雷芬, 江光群, 周亚林, 甘小丽, 许静茹, 向新志, 彭斌. 某化工园区附近学龄儿童血液中三种典型卤代烃的内暴露情况研究[J]. 环境卫生学杂志, 2023, 13(10): 724-731, 751. DOI: 10.13421/j.cnki.hjwsxzz.2023.10.002
    引用本文: 高四红, 邹钦培, 雷芬, 江光群, 周亚林, 甘小丽, 许静茹, 向新志, 彭斌. 某化工园区附近学龄儿童血液中三种典型卤代烃的内暴露情况研究[J]. 环境卫生学杂志, 2023, 13(10): 724-731, 751. DOI: 10.13421/j.cnki.hjwsxzz.2023.10.002
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    GAO Si-hong, ZOU Qin-pei, LEI Fen, JIANG Guang-qun, ZHOU Ya-lin, GAN Xiao-li, XU Jing-ru, XIANG Xin-zhi, PENG Bin. Study on internal exposure of three typical halogenated hydrocarbons in blood of children near a chemical industrial park[J]. Journal of Environmental Hygiene, 2023, 13(10): 724-731, 751. DOI: 10.13421/j.cnki.hjwsxzz.2023.10.002
    Citation: GAO Si-hong, ZOU Qin-pei, LEI Fen, JIANG Guang-qun, ZHOU Ya-lin, GAN Xiao-li, XU Jing-ru, XIANG Xin-zhi, PENG Bin. Study on internal exposure of three typical halogenated hydrocarbons in blood of children near a chemical industrial park[J]. Journal of Environmental Hygiene, 2023, 13(10): 724-731, 751. DOI: 10.13421/j.cnki.hjwsxzz.2023.10.002
    shu

    某化工园区附近学龄儿童血液中三种典型卤代烃的内暴露情况研究

    Study on internal exposure of three typical halogenated hydrocarbons in blood of children near a chemical industrial park

      摘要
    • 摘要:
      目的 探讨某化工园区附近学龄儿童体内三氯甲烷、四氯化碳和三氯乙烯的内暴露情况及其对血液指标的影响。
      方法 于2016年选择某化工园区主导风向上风向1 km处的中学作为暴露组, 在距离该化工园区上风向25 km地区选择某所中学作为对照组。采用整群随机抽样方法, 在暴露组内抽取符合纳入排除标准的调查对象作为暴露组儿童, 同时按照1∶1匹配的原则, 在对照组内选择与暴露组儿童相同年龄和性别的在校学生作为对照组儿童, 共纳入184名调查对象。采集环境空气、饮用水及调查对象血液样品, 检测三氯甲烷、四氯化碳和三氯乙烯的浓度及静脉血血液学指标。
      结果 暴露组饮用水中三氯甲烷、四氯化碳和三氯乙烯的检出率高于对照组(P < 0.05)。暴露组儿童血液中三氯甲烷和四氯化碳的内暴露水平和检出率均高于对照组(P < 0.05)。暴露组儿童的单核细胞计数及血红蛋白、白蛋白、谷丙转氨酶浓度均低于对照组, 血小板计数高于对照组(P < 0.05)。暴露组儿童血液中三氯甲烷的检出风险是对照组的3.13倍(OR=3.13, 95% CI: 1.20, 8.15), 四氯化碳的检出风险是对照组的7.02倍(OR=7.02, 95% CI: 1.44, 34.34)。在校正了年龄、性别、BMI、被动吸烟情况等因素后, 三氯甲烷对单核细胞计数以及四氯化碳对血红蛋白浓度均存在非线性影响(P < 0.05)。
      结论 暴露组儿童血液中三氯甲烷和四氯化碳的内暴露水平和检出率显著高于对照组, 且三氯甲烷暴露与单核细胞计数有关联, 四氯化碳暴露与血红蛋白浓度有关联。

       

      Abstract:
      Objective To investigate the internal exposure of trichloromethane, carbon tetrachloride, and trichloroethylene in school-age children near a chemical industrial park, and to analyze their effect on hematological indices.
      Methods In 2016, a middle school located 1 km upwind of a chemical industrial park was selected as the exposure group, and a middle school located 25 km upwind of the chemical industrial park was selected as the control group. Students in the exposure group who met the inclusion and exclusion criteria were selected as the exposure group, and students of the same age and gender in the control group, according to the principle of 1∶1 matching, were selected as the control group by the cluster random sampling method. A total of 184 students were included. Ambient air, drinking water, and venous blood samples of students were collected to measure the concentrations of trichloromethane, carbon tetrachloride, and trichloroethylene, and the hematological indices of blood.
      Results The detection rates of trichloromethane, carbon tetrachloride, and trichloroethylene in drinking water were significantly higher in the exposure group than those in the control group(P < 0.05). The internal exposure levels and detection rates of trichloromethane and carbon tetrachloride in blood samples in the exposure group were significantly higher than those in the control group(P < 0.05). The monocyte count and the concentrations of hemoglobin, albumin, and alanine aminotransferase in the exposure group were significantly lower than those in the control group, while the platelet count in the exposure group was significantly higher than that in the control group(P < 0.05). The detection risk of trichloromethane in blood samples in the exposure group was 3.13 times that in the control group(OR=3.13, 95% CI: 1.20, 8.15), and the detection risk of carbon tetrachloride was 7.02 times that in the control group(OR=7.02, 95% CI: 1.44, 34.34). After adjusting for age, gender, body mass index, and passive smoking, trichloromethane had a nonlinear effect on monocyte count, and carbon tetrachloride had a nonlinear effect on hemoglobin concentration(P < 0.05).
      Conclusion The internal exposure levels and detection rates of trichloromethane and carbon tetrachloride in blood samples in the exposure group are significantly higher than those in the control group. Meanwhile, trichloromethane exposure is related to monocyte count, and carbon tetrachloride exposure is related to hemoglobin concentration.

       

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