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    刘雪娇, 陈佳, 袁蕊, 路凤, 牛彦麟. 北京市大气污染物暴露对骨质疏松性骨折入院量的短期效应[J]. 环境卫生学杂志, 2023, 13(9): 635-641. DOI: 10.13421/j.cnki.hjwsxzz.2023.09.001
    引用本文: 刘雪娇, 陈佳, 袁蕊, 路凤, 牛彦麟. 北京市大气污染物暴露对骨质疏松性骨折入院量的短期效应[J]. 环境卫生学杂志, 2023, 13(9): 635-641. DOI: 10.13421/j.cnki.hjwsxzz.2023.09.001
    shu
    LIU Xue-jiao, CHEN Jia, YUAN Rui, LU Feng, NIU Yan-lin. Short-term effect of air pollutants exposure on hospital admissions for osteoporotic fractures in Beijing, China[J]. Journal of Environmental Hygiene, 2023, 13(9): 635-641. DOI: 10.13421/j.cnki.hjwsxzz.2023.09.001
    Citation: LIU Xue-jiao, CHEN Jia, YUAN Rui, LU Feng, NIU Yan-lin. Short-term effect of air pollutants exposure on hospital admissions for osteoporotic fractures in Beijing, China[J]. Journal of Environmental Hygiene, 2023, 13(9): 635-641. DOI: 10.13421/j.cnki.hjwsxzz.2023.09.001
    shu

    北京市大气污染物暴露对骨质疏松性骨折入院量的短期效应

    Short-term effect of air pollutants exposure on hospital admissions for osteoporotic fractures in Beijing, China

      摘要
    • 摘要:
      目的 探讨北京市大气污染物暴露对骨质疏松性骨折入院量的影响。
      方法 收集北京市某三甲医院2016年1月1日至2018年12月31日入院的骨质疏松性骨折患者入院信息和同期的大气污染物、气象数据, 采用广义相加模型(generalized additive models, GAM)分析大气污染物暴露对骨质疏松性骨折入院量的影响。
      结果 2016—2018年, 北京市空气环境中PM2.5、PM10、NO2、O3-8 h、SO2和CO的日均质量浓度分别为45、77、39、54、5和0.8 mg/m3, 骨质疏松性骨折每日入院量M(P25, P75)为8(6, 10)例。单污染物模型显示, PM2.5在lag 6 d和lag 7 d的效应具有统计学意义(P < 0.05), PM2.5质量浓度每增加10 μg/m3, 可导致骨折入院量分别增加0.56% (95% CI: 0.06%, 1.06%)和0.52% (95% CI: 0.02%, 1.03%); SO2在lag 6 d、lag 7 d、lag 06 d和lag 07 d的效应具有统计学意义(P < 0.05), SO2质量浓度每增加10 μg/m3, 对应的ER(95% CI)值分别为4.74%(0.47%, 9.20%)、5.19%(0.99%, 9.57%)、11.02%(0.54%, 22.59%)和15.99%(4.33%, 28.94%); 其余大气污染物对骨折入院量影响无统计学意义。分层分析结果显示, PM2.5和SO2对男性患者影响更大, 而SO2在冷季对患者影响更大。
      结论 短期暴露于PM2.5和SO2后, 可显著增加骨折入院风险, 且效应存在滞后性, 对不同性别患者和不同季节之间风险存在一定差异。

       

      Abstract:
      Objective To explore the effect of exposure to air pollutants on hospital admissions for osteoporotic fractures in Beijing, China.
      Methods The information on admissions of patients with osteoporotic fractures who were admitted to a grade A tertiary hospital in Beijing from January 1, 2016 to December 31, 2018, and the data on air pollutants and meteorological factors during the same period were collected. The effect of exposure to air pollutants on hospital admissions for osteoporotic fractures was analyzed by generalized additive models(GAM).
      Results From 2016 to 2018, the average daily mass concentrations of PM2.5, PM10, NO2, O3-8 h, SO2, and CO in Beijing were 45, 77, 39, 54, 5, and 0.8 mg/m3, respectively. The median(P25, P75) of daily admissions for osteoporotic fractures were 8 (6, 10) cases. The single pollutant model showed that an increase of 10 μg/m3 in PM2.5 mass concentration could lead to increases of 0.56% (95% CI: 0.06%, 1.06%) and 0.52% (95% CI: 0.02%, 1.03%) in fracture admissions on lag 6 day and lag 7 day, respectively. An increase of 10 μg/m3 in SO2 mass concentration could lead to increases of 4.74% (95%CI: 0.47%, 9.20%), 5.19% (95%CI: 0.99%, 9.57%), 11.02% (95%CI: 0.54%, 22.59%) and 15.99% (95%CI: 4.33%, 28.94%) in fracture admissions on lag6 day, lag7 day, lag06 days, and lag07 days, respectively. Other air pollutants showed no significant effect on fracture admissions. Stratified analysis showed that PM2.5 and SO2 had a greater impact on male patients, while SO2 had a greater impact on patients in the cold season.
      Conclusion Short-term exposure to PM2.5 and SO2 can significantly increase the risk of fracture admission, with a lag effect, and the effect varies by gender and season.

       

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