Abstract: With the outbreak of the novel coronavirus pneumonia(COVID-19) in early 2020, Leishenshan Hospital was quickly established and put into use. As an important part of preventing the spread of the epidemic, the harmless treatment of hospital sewage is essential. In this survey, continuous online testing equipment was used to monitor the effect of hospital sewage treatment, and the consistency evaluation was conducted in conjunction with sampling testing. The online monitoring results showed that the average total residual chlorine was (8.7±0.8)mg/L, the average ammonia nitrogen was (3.6±1.2)mg/L, the average pH was 6.6±0.2, and the average COD was (98±55)mg/L; the sampling test results showed that both Salmonella and Shigella Not detected; the total residual chlorine and pH value detected by the two methods of sampling and continuous online monitoring were not statistically different (P>0.05), and the fecal coliforms were all ≤100 MPN/L. The results show that the sewage discharge of Leishenshan Hospital meets the Water Pollution Discharge Standard for Medical Institutions, the hospital sewage collection pipe network should be set up separately for different sources such as isolation area wards, medical technical rooms, and clean areas to avoid cross-contamination of the drainage system, and help protect medical staff during the epidemic.