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    杨思宇, 李寿江, 王斌, 李智文, 闫赖赖, 陈曦. 山西女性居民发铝与高血压发生风险的关联性研究[J]. 环境卫生学杂志, 2021, 11(4): 332-336. DOI: 10.13421/j.cnki.hjwsxzz.2021.04.005
    引用本文: 杨思宇, 李寿江, 王斌, 李智文, 闫赖赖, 陈曦. 山西女性居民发铝与高血压发生风险的关联性研究[J]. 环境卫生学杂志, 2021, 11(4): 332-336. DOI: 10.13421/j.cnki.hjwsxzz.2021.04.005
    shu
    YANG Siyu, LI Shoujiang, WANG Bin, LI Zhiwen, YAN Lailai, CHEN Xi. Relationship between Hair Aluminum Concentrations and Hypertension Risk among Female Residents in Shanxi Province of China[J]. Journal of Environmental Hygiene, 2021, 11(4): 332-336. DOI: 10.13421/j.cnki.hjwsxzz.2021.04.005
    Citation: YANG Siyu, LI Shoujiang, WANG Bin, LI Zhiwen, YAN Lailai, CHEN Xi. Relationship between Hair Aluminum Concentrations and Hypertension Risk among Female Residents in Shanxi Province of China[J]. Journal of Environmental Hygiene, 2021, 11(4): 332-336. DOI: 10.13421/j.cnki.hjwsxzz.2021.04.005
    shu

    山西女性居民发铝与高血压发生风险的关联性研究

    Relationship between Hair Aluminum Concentrations and Hypertension Risk among Female Residents in Shanxi Province of China

      摘要
    • 摘要:
      目的 考察我国山西地区女性居民头发中铝元素含量，探讨头发中铝元素与高血压发生风险的关联性。
      方法 在山西共募集398名女性居民，其中高血压疾病患者163人(病例组)，健康女性235人(对照组)。收集研究对象的人口学信息，进行相关的体格检查，收集头发样品，用电感耦合等离子体质谱仪检测头发中的铝元素含量。
      结果 病例组发铝含量M(P25, P75)为18.1 (10.5，26.3)μg/g，显著高于对照组的12.8(8.63，21.5)μg/g。二分类Logistic回归单因素OR值(95%CI)为2.00 (1.33, 3.00)，调整OR值为1.65(1.02, 2.66)。发铝含量与高血压风险存在剂量反应关系。发铝含量与收缩压、舒张压、心率之间均呈正相关，相关系数分别为0.185、0.157、0.231。
      结论 女性人群长期铝暴露可能增加高血压患病风险。

       

      Abstract:
      Objective To investigate the hair aluminum (Al) concentration of female residents in Shanxi province of China and its relationship with the risk of hypertension.
      Methods A total of 398 female residents were recruited in Shanxi province, among whom there were 163 patients with hypertension (case group) and 235 healthy women (control group). Demographic data of these residents were collected, and physical examination was performed. The hair samples of the residents were collected to measure the concentration of Al by inductively coupled plasma mass spectrometry.
      Results The case group had a significantly higher hair Al concentration M (25%-75%) than the control group 18.1 (10.5-26.3)μg/g vs 12.8 (8.63-21.5)μg/g. The binary logistic regression analysis showed a univariate odds ratio (OR) of 2.00 (95% CI: 1.33-3.00) and an adjusted OR of 1.65 (95% CI: 1.02-2.66). A dose-response relationship was observed between hair Al concentration and hypertension risk. Hair Al concentration was significantly positively correlated with systolic pressure, diastolic pressure, and heart rate with correlation coefficients of 0.185, 0.157 and 0.231, respectively.
      Conclusion Long-term exposure to Al may increase the risk of hypertension in women.

       

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