Abstract: Effective response to public health emergencies is one of the core capacities of professionals in public health and preventive medicine. In addition to introducing the establishment of the virtual simulation experimental teaching program of post-typhoon environmental health emergency response, the authors have also applied the program to the teaching practice of preventive medicine and analyzed the teaching effect in preventive medicine for undergraduates. The analytical results show that the virtual simulation experimental teaching, as a new experimental teaching mode, can effectively supplement the inadequacy in traditional experimental teaching and environmental health emergency drills, which is helpful in advancing educational informationization and improving teaching quality.