多溴联苯醚与2型糖尿病关联性的Meta分析

李美艳; 王永治; 阿依古丽·阿里木; 海且木汗·阿不杜热曼; 刘早玲

doi:10.13421/j.cnki.hjwsxzz.2020.05.012

多溴联苯醚与2型糖尿病关联性的Meta分析

Relationship between Polybrominated Diphenyl Ethers and Type 2 Diabetes Mellitus: A Meta-Analysis

摘要

摘要:
目的利用Meta分析方法评价多溴联苯醚（polybrominated diphenyl ethers，PBDEs）与2型糖尿病（type 2 diabetes mellitus，T2DM）的关联性。
方法计算机检索万方数据库、中国知网、维普中文科技期刊数据库、中国生物医学文献服务系统等中文数据库及PubMed、OVID、Research Gate、Cochrane databases等英文数据库，收集研究PBDEs与T2DM关联性的观察性研究。经过文献筛选、资料提取和质量评价后，采用RevMan5.3软件进行Meta分析。
结果共纳入7篇合格文献，包括病例和对照为1 276、5 135例。Meta分析显示，暴露于PBDEs与T2DM发病风险有关，OR（95%CI）值为1.47（1.16，1.85），P < 0.05。对PBDEs的常见的同系物进行单独分析，发现BDE-47与T2DM发病风险有关，OR（95%CI）值为1.52（1.08，2.14），P < 0.05。BDE-99、BDE-153、BDE-183与T2DM发病风险均无关。
结论 PBDEs暴露很可能是T2DM发病的危险因素，但其病因学方面的联系，仍需要进一步高质量的研究加以证实。

Abstract:
Objective To evaluate the relationship between polybrominated diphenyl ethers (PBDEs) and type 2 diabetes mellitus (T2DM) via Meta-analysis.
Methods Chinese databases such as Wanfang Data, CNKI, VIP, and SinoMed, and English databases such as PubMed, OVID, Research Gate, and Cochrane databases were searched for the observational studies on the relationship between PBDEs and T2DM. After literature screening, data extraction, and quality evaluation, RevMan5.3 software was used for Meta-analysis.
Results A total of 7 eligible studies with 1276 cases and 5135 controls were included. The Meta-analysis showed that exposure to PBDEs was related with the risk of T2DM (OR=1.47, 95% CI:1.16-1.85, P < 0.05). The homologues of PBDEs were analyzed separately, and the result showed that BDE-47 was related with the risk of T2DM(OR=1.52, 95%CI:1.08-2.14, P < 0.05), while BDE-99, BDE-153, and BDE-183 were not related with the risk of T2DM.
Conclusion PBDEs exposure is likely to be a risk factor for T2DM, but their etiological link still needs to be confirmed by further high-quality research.

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