超高效液相色谱串联质谱法测定饮用水中双酚S、双酚F和双酚A

周小新; 胡小键

doi:10.13421/j.cnki.hjwsxzz.2020.02.020

超高效液相色谱串联质谱法测定饮用水中双酚S、双酚F和双酚A

Direct Determination of Bisphenol S, Bisphenol F, and Bisphenol A in Drinking Water by Ultra-performance Liquid Chromatography-Mass Spectrometry

摘要

摘要:
目的建立饮用水中双酚S（BPS）、双酚F（BPF）和双酚A（BPA）的超高效液相色谱—串联质谱（UPLC-MS/MS）直接测定方法。
方法以甲醇—水为流动相梯度洗脱，水样经Waters ACQUITY UPLC^©HSS T₃色谱柱分离，采用负离子电喷雾多反应监测模式进行检测，外标法定量。
结果 UPLC-MS/MS色谱分离良好，BPS、BPF和BPA在（0.5~50.0）μg/L浓度范围内线性相关系数均大于0.997，BPS、BPF和BPA的方法检出限分别为0.002、0.05和0.15 μg/L，加标回收率范围为90.1%~108%，相对标准偏差（RSD）为0.57%~5.90%。
结论 UPLC-MS/MS操作简便、分析速度快、灵敏度高，适用于饮用水中双酚类化合物的测定。

Abstract:
Objective To establish an ultra-performance liquid chromatography-mass spectrometry method for direct determination of bisphenol S (BPS), bisphenol F (BPF), and bisphenol A (BPA) in drinking water.
Methods With a mobile phase of methanol-water for gradient elution, the water samples were separated on a Waters Acquity UPLC-HSS T3 column (2.1 mm×100 nm, 1.8 μm) and were then detected by electrospray ionization mass spectrometry in multi-reaction monitoring mode, and the external standard method was used for quantification.
Results This method had good chromatographic separation, and BPS, BPF, and BPA had a linear correlation coefficient of >0.997 within the range of(0.05~50.0) μg/L. The method detection limits of BPS, BPF, and BPA were 0.002, 0.05, and 0.15 μg/L, respectively, and the recovery of standard addition ranged from 90.1% to 108%, with relative standard deviations of 0.57%~5.90%.
Conclusion The method is simple, rapid, and sensitive and can be used for determining bisphenol compounds in drinking water.

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