河南省三市一般人群血浆中铜和锌分布特征及铜锌比值研究

武鑫; 潘亚娟; 赵玮; 闫慧芳

doi:10.13421/j.cnki.hjwsxzz.2018.05.009

河南省三市一般人群血浆中铜和锌分布特征及铜锌比值研究

Distributional Characteristics of Copper and Zinc in Plasma and Cu/Zn Ratio in General Population of Three Cities in Henan Province

摘要

摘要:
目的了解河南省三市一般人群血浆中铜、锌分布特征，并分析其分布特点。
方法采取整群随机抽样的方法，于2009—2010年在河南省濮阳、焦作及平顶山3个城市的区县中，抽取了1.866名（6~60）岁人群作为调查对象，进行问卷调查及血液样品采集。应用电感耦合等离子体发射光谱法检测样品中铜、锌浓度，分析河南省三市一般人群血浆中铜、锌浓度在不同年龄、性别、地区的分布特征。
结果调查对象血浆铜均数为933 μg/L，中位数为923 μg/L，P_2.5和P_97.5分别为612和1.355 μg/L。男性血浆铜浓度低于女性，差别有统计学意义（P < 0.01）。不同年龄组血浆铜差异有统计学意义（P < 0.01），其中（46~60）岁年龄组最高（中位数1.003 μg/L），（17~20）岁年龄组最低（中位数810 μg/L）；河南省濮阳、焦作和平顶山等三市一般人群血浆铜差异有统计学意义（P < 0.01），其中焦作市最高（中位数933 μg/L），平顶山市最低（中位数893 μg/L）。调查对象血浆锌均数为878 μg/L，中位数为859 μg/L，P_2.5和P_97.5分别为618和1.217 μg/L。男性血浆锌浓度高于女性（P < 0.01）；不同年龄组血浆锌差异有统计学意义（P < 0.01），其中（21~30）岁年龄组最高（中位数934 μg/L），（13~16）岁年龄组最低（中位数805 μg/L）；河南省濮阳、焦作和平顶山三市一般人群血浆锌中位数分别为887、884和801 μg/L，差异有统计学意义（P < 0.01）。不同性别、年龄、地区之间血浆铜锌比值均存在显著性差异（P < 0.01）。
结论河南省三市一般人群血浆铜、锌和铜锌比值在不同性别、年龄以及地区间均存在差异。

Abstract:
Objectives To understand the distributional characteristics of copper and zinc in plasma of general population in three cities of Henan province.
Methods A total of 1 866 (6~60 year-old) subjects were selected by a cluster random sampling method in 2009-2010 from 3 cities of Henan province:Puyang, Jiaozuo and Pingdingshan. Questionnaire, and blood samples were collected. Copper and zinc levels in plasma were determined by inductively coupled plasma optical emission spectrometer (ICP-OES). The distributional characteristics of copper and zinc in plasma in different age, gender and region groups in Henan Province were analyzed.
Results The mean and median levels of plasma Cu were 933 and 923 μg/L, and the mean and median of P_2.5 and P_97.5 levels were 612 and 1 355 μg/L respectively. The levels of plasma copper in male was lower than that in female (P < 0.01). Plasma copper was different in different age groups (P < 0.01), it was the highest in (46~60) year-old group (median 1.003μg/L), and it was the lowest in (17~20) year-old group (median 810 μg/L); Plasma copper in Jiaozuo was the highest (median 933 μg/L) and that in Pingdingshan was the lowest (median 893 μg/L), it was significantly different in three cities (P < 0.01). The mean and median of plasma Zn were 878 and 859 μg/L, and the mean and median of P_2.5 and P_97.5 were 618 μg/L and 1.217 μg/L respectively. The level of plasma Zn was higher in male than that in female (P < 0.01); Plasma zinc level was significantly different in different age groups (P < 0.01), the highest was in (21~30) year-old group (median 934 μg/L), and the lowest was in 13-16 year-old group (median 805 μg/L); The median of plasma zinc in Puyang, Jiaozuo and Pingdingshan were 887, 884 and 801 μg/L, respectively, and the difference was statistically significant (P < 0.01). Plasma Cu/Zn ratio was significantly different in different gender, age and region groups (P < 0.01).
Conclusions The level of plasma copper, zinc and Cu/Zn ratio in the general population of three cities in Henan province was different in different gender, age and region groups.

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