Abstract: Organophosphorus pesticides are the most widely used pesticides in China. In recent years, more and more attention has been paid to the combined toxicity of organophosphorus pesticides. The effect of combined toxicity of organophosphorus pesticides on human health, including genetic toxicity, carcinogenicity, reproductive toxicity, neurotoxicity and immunotoxicity were summarized in this paper. And the possible mechanism of action were also reviewed and discussed in order to establish and improve an efficient and scientific use of organophosphorus pesticides and to provide corresponding toxicological basis for risk assessment.