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    晓开提·依不拉音, 玛依热·热夏提, 康宏, 徐涛, 纪元. 乌鲁木齐市大气细颗粒物水溶成分和非水溶成分对人正常肺上皮细胞的毒性作用[J]. 环境卫生学杂志, 2017, 7(2): 85-89. DOI: 10.13421/j.cnki.hjwsxzz.2017.02.001
    引用本文: 晓开提·依不拉音, 玛依热·热夏提, 康宏, 徐涛, 纪元. 乌鲁木齐市大气细颗粒物水溶成分和非水溶成分对人正常肺上皮细胞的毒性作用[J]. 环境卫生学杂志, 2017, 7(2): 85-89. DOI: 10.13421/j.cnki.hjwsxzz.2017.02.001
    shu
    XIAOKAIYI·Yibulayin, MAYIRE·Rexiati, KANG Hong, XU Tao, JI Yuan. Toxic Effect of Soluble and Insoluble Components of PM2.5 in Urumqi City on Human Normal Lung Epithelial Cells[J]. Journal of Environmental Hygiene, 2017, 7(2): 85-89. DOI: 10.13421/j.cnki.hjwsxzz.2017.02.001
    Citation: XIAOKAIYI·Yibulayin, MAYIRE·Rexiati, KANG Hong, XU Tao, JI Yuan. Toxic Effect of Soluble and Insoluble Components of PM2.5 in Urumqi City on Human Normal Lung Epithelial Cells[J]. Journal of Environmental Hygiene, 2017, 7(2): 85-89. DOI: 10.13421/j.cnki.hjwsxzz.2017.02.001
    shu

    乌鲁木齐市大气细颗粒物水溶成分和非水溶成分对人正常肺上皮细胞的毒性作用

    Toxic Effect of Soluble and Insoluble Components of PM2.5 in Urumqi City on Human Normal Lung Epithelial Cells

      摘要
    • 摘要:
      目的 用大气细颗粒物（PM2.5）染毒人正常肺上皮细胞（BEAS-2B细胞），探讨大气细颗粒物（PM2.5）不同成分对人正常肺上皮细胞（BEAS-2B）的细胞毒性和氧化损伤。
      方法 采集乌鲁木齐市大气细颗粒物（PM2.5），实验细胞为人正常肺上皮细胞株BEAS-2B细胞。为比较细颗粒物不同成分对细胞毒性的大小，超声震荡洗脱石英纤维滤膜中的细颗粒物，分析其水溶成分和非水溶成分的毒性。
      结果 对PM2.5中水溶成分和非水溶成分进行剂量为50μg/mL、100μg/mL、200μg/mL和300μg/mL的浓度染毒，结果显示水溶成分的细胞毒性高于非水溶成分（P < 0.01）。
      结论 大气细颗粒物（PM2.5）可导致细胞损伤，并且组成成分的不同可以导致其对细胞毒性的差异。

       

      Abstract:
      Objective To investigate the cytotoxicity and oxidative damage of different components of atmospheric fine particulate matter (PM2.5) collected from Urumqi city on human normal lung epithelial cell (BEAS-2B).
      Method The exposure of human normal lung epithelial cells (BEAS-2B) to the soluble component and insoluble component of PM2.5 was used as an experimental model to compare the cytotoxicity of different components of PM2.5 eluted from quartz fiber filters.
      Results The cytotoxicity of soluble components was more toxic than insoluble components on BEAS-2B cells exposed to 50 μg/mL, 100 μg/mL, 200 μg/mL and 300 μg/mL PM2.5 (P < 0.01).
      Conclusion Atmospheric fine particulate matter (PM2.5) can cause cell damage, and the different composition of PM2.5 can lead to different cytotoxicity.

       

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