Objective  To analyze the factors influencing the prevalence of hand-foot-mouth disease(HFMD) in Shijiazhuang and to take targeted intervention and control measures.

Methods  A case-control study was applied by questionnaire survey.150 HFMD cases diagnosed in Jan 2011 to Dec 2013 in a county with higher incidence of HFMD were selected as subjects and 300 healthy children living in the same region were selected as controls.

Results  The number of rooms in a household, opening windows for ventilation regularly, the way of waste disposal, the type of drinking water, the health and culture of caregivers, the habit of washing hands, the frequency of drying bedding under sun light, the health status of children, the habit of chewing finger and joy, drinking unboiled water, the habit of cleaning utensils, receiving propaganda for HFMD, establishing morning and afternoon inspection system in childcare facilities were potential influencing factors entering the regression equation of single-factor analysis. The number of rooms in a household, opening windows, chewing joy, the habit of washing hands and the history of contacting with HFMD patients were potential influencing factors entering the regression equation of multi-factor analysis.

Conclusion  The influencing factors of HFMD are closely related with the environment and individual life habits. Comprehensive measures should be taken for the control and prevent of HFMD.