Objective  To explore the effect of air pollution on lung function and local non-special immunity of pupils in Guiyang.

Methods  Five hundred and thirty 8~10 year-old subjects living in polluted area or relative clean area in Guiyang city were selected by cluster sampling. The lung function of forced vital capacity (FVC), forced expiratory volume in 1 second (FEV_1.0), maximum mid-expiratory flow rate (MMEF), peak expiratory flow rate (PEF), maximum voluntary ventilation per minute (MVV), and local non-special immunity (saliva lysozyme) were measured.

Results  FVC and EFV_1.0 of 8 year-old pupils living in polluted area were significantly lower than those living in relative clean area (P <0.05). FVC and PEF of 9 year-old pupils living in polluted area were significantly lower than those living in relative clean area (P <0.05). FVC, FEV_1.0, MMEF, PEF and MVV of 10 year-old pupils living in polluted area were significantly lower than those living in relative clean area(P <0.05). The activity of saliva lysozyme of 9 year-old pupils living in polluted area was significantly lower than those living in relative clean area (P <0.05). Lung function indexes were positively correlated with age, gender and body height. Local non-special immunity index was positively correlated with age.

Conclusion  Air pollution might have effect on the lung function and local non-special immunity of pupils. More attention should be paid to the prevention and control of air pollution by relevant department of the government.